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Viral load, also known as viral burden, is a numerical expression of the quantity of virus in a given volume of fluid, including biological and environmental specimens. It is not to be confused with viral titre or viral titer , which depends on the assay.
Undetectable = Untransmittable (U=U) is a message used in HIV campaigns. It means that if someone has an undetectable viral load, they cannot sexually transmit HIV to others. [1] U=U is supported by numerous health groups and organisations worldwide, including the World Health Organization (WHO). [2]
Virological failure is defined as the failure to meet a specific target of antiviral drug treatment, namely the non-attainment or non-maintenance of undetectable viral load, particularly in the treatment of HIV. As antiretroviral therapy is evaluated by detecting the amount of copies of the virus in blood samples, the concept of virological ...
The combination of Rekambys and Vocabria injection is intended for maintenance treatment of adults who have undetectable HIV levels in the blood (viral load less than 50 copies/mL) with their current ARV treatment, and when the virus has not developed resistance to a certain class of anti-HIV medicines called non-nucleoside reverse ...
Suppressing the viral load to undetectable levels (<50 copies per ml) is the primary goal of ART. [56] This should happen by 24 weeks after starting combination therapy. [83] Viral load monitoring is the most important predictor of response to treatment with ART. [84] Lack of viral load suppression on ART is termed virologic failure.
Research has shown (for both same-sex and opposite-sex couples) that HIV is not contagious during sexual intercourse without a condom if the HIV-positive partner has a consistently undetectable viral load. [5] [6] HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4 + T cells), macrophages, and dendritic ...
However, an overwhelming body of clinical evidence has demonstrated the U=U rule - if someone's viral load is undetectable (<200 viral copies per mL) they are untransmissible. Essentially this means if a person living with HIV is well controlled on medications with a viral load less than 200, they cannot transmit HIV to their partners via ...
Having a low viral load decreases the chance of transmitting HIV. A person living with HIV who is taking effective antiretroviral therapy will have a viral load that becomes so low, it is undetectable (less than 50 copies of virus per milliliter). [5] Undetectable viral loads are untransmittable. [6]
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