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DMPA, under brand names such as Depo-Provera and Depo-SubQ Provera 104, is used in hormonal birth control as a long-lasting progestogen-only injectable contraceptive to prevent pregnancy in women. [ 38 ] [ 39 ] It is given by intramuscular or subcutaneous injection and forms a long-lasting depot , from which it is slowly released over a period ...
Provera: Progestogen: Oral: 2.5–40 mg/day Depo-Provera: Progestogen: IM: 150 mg every 3 mos: Depo-SubQ Provera 104: Progestogen: SC: 104 mg every 3 mos ...
Depot MPA (DMPA) and EC/MPA were developed by Upjohn in the 1960s. [12] [13] DMPA (brand name Depo-Provera) was introduced for use as a progestogen-only injectable contraceptive for the first time outside of the United States in 1969 and was subsequently approved for use in birth control in the United States in 1992.
The first progestogen-only contraceptive was introduced in 1969: Depo-Provera, a high-dose progestin injection. [54] Over the next decade and a half, other types of progestogen-only contraceptive were developed: a low-dose progestogen only pill (1973); [ 55 ] Progestasert, the first hormonal intrauterine device (1976); [ 56 ] and Norplant , the ...
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Also it is not clear how rapidly it is hydrolyzed. Hence it may not be a true prodrug. Finally MPA is the active ingredient of Depo-Provera which can be used as a injectable contraceptive whose effects last for months. Hence the reason for the acetate ester maybe to increase the hydrophobicity and thereby increase the half-life of the drug.
WASHINGTON (Reuters) -The mother of Austin Tice, a U.S. journalist captured over 12 years ago in Syria, said on Friday that her family had information that he is still alive. “We have from a ...
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