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  2. Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Parkinson's_disease

    Parkinson's can be narrowly defined as a genetic disease, as rare inherited gene variants have been firmly linked to monogenic PD, and the majority of sporadic cases carry variants that increase PD risk. [57] [61] [62] PD heritability is estimated to range from 22 to 40 percent. [57]

  3. Causes of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Causes_of_Parkinson's_disease

    Traditionally, Parkinson's disease has been considered a non-genetic disorder. However, around 15% of individuals with PD have a first-degree relative who has the disease. [ 8 ] At least 5–15% of cases are known to occur because of a mutation in one of several specific genes, transmitted in either an autosomal-dominant or autosomal-recessive ...

  4. Parkinsonism - Wikipedia

    en.wikipedia.org/wiki/Parkinsonism

    Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. [1] [2] Both hypokinetic (bradykinesia and akinesia) as well as hyperkinetic (cogwheel rigidity and tremors at rest) features are displayed by Parkinsonism. [3]

  5. Research in Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Research_in_Parkinson's...

    Several current studies are examining the genetic factors of Parkinson's disease. [17] An example of genetic research is a recent study that investigated the GBA gene as a suspected cause of early-onset Parkinson's. [18] A genetic study involving researchers from BGI Genomics reveals the genetic cause of Parkinson's disease. [19]

  6. What is Parkinson’s disease? - AOL

    www.aol.com/lifestyle/brett-favre-reveals...

    Parkinson’s disease symptoms. Symptoms of the disease can vary by person, but the NIA says these are the four main symptoms of Parkinson’s: Tremor in hands, arms, legs, jaw or head.

  7. Animal models of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Animal_Models_of_Parkinson...

    Parkinson's disease is a neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of the dopamine neurons in the brain, results in motor dysfunction, ultimately causing the four cardinal symptoms of PD: tremor, rigidity, postural instability, and bradykinesia . [ 1 ]

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