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Keratoconus, a progressive, noninflammatory, bilateral, asymmetric disease, characterized by paraxial stromal thinning and weakening that leads to corneal surface distortion. [ 2 ] Keratoglobus , a rare noninflammatory corneal thinning disorder, characterised by generalised thinning and globular protrusion of the cornea.
In 2016, however, the FDA approved cross-linking surgery as a treatment for keratoconus and recommended that a registry system should be set-up to evaluate the long-term treatment effect. [ 9 ] [ 70 ] The Save Sight Keratoconus Registry is an international database of keratoconus patients that is tracking outcomes of cross-linking in patients ...
Corneal cross-linking (CXL) with riboflavin (vitamin B 2) and UV-A light is a surgical treatment for corneal ectasia such as keratoconus, PMD, and post-LASIK ectasia. It is used in an attempt to make the cornea stronger. According to a 2015 Cochrane review, there is insufficient evidence to determine if it is useful in keratoconus. [2]
KC6 ("Keratoconus gene 6") is a novel gene located on chromosome 18 at p12.3. It was discovered by Rabinowitz et al. (2005) [1] in a study whose aims were finding genes expressed in human cornea and increasing the knowledge of molecular changes in keratoconus. It lies adjacent to the PIK3C3 gene, but is apparently non-protein coding. Its ...
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Keratoconus, a progressive thinning of the cornea, is a common corneal disorder. Keratoconus occurring after refractive surgery is called Corneal Ectasia. It is believed that additional thinning of the cornea via refractive surgery may contribute to advancement of the disease [31] that may lead to the need for a corneal transplant.
Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft). When the entire cornea is replaced it is known as penetrating keratoplasty and when only part of the cornea is replaced it is known as lamellar keratoplasty.