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Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. [ 5 ] [ 6 ] It is ubiquitously expressed in many tissues and cell types. [ 7 ] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis . [ 8 ]
Elastic arteries include the largest arteries in the body, those closest to the heart. They give rise to medium-sized vessels known as distributing arteries (or muscular arteries ). The pulmonary arteries , the aorta , and its branches together comprise the body's system of elastic arteries.
The process of glycation does not only damage the collagen existing in the body but also makes some alterations to its stability. When an individual consumes excessive amounts of sugar, the glycation process converts collagen into an unstable type 1, which becomes more vulnerable and can be easily broken down, potentially leading to premature ...
Type I collagen is the type that comprises more than 90 percent of the collagen in the human body and provides structure to skin, bones, ligaments, and tendons, she explains. Type II forms the ...
Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. [3] In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and accounts for 6% of the weight to skeletal muscle. [4] The fibroblast is the most common cell creating collagen in ...
Type I collagen production is inhibited by the inability of the altered procollagen strands to associate and form the triple-stranded, ropelike structure of mature collagen. These alterations negatively affect tissues that are rich in type I collagen, such as the skin, bones, teeth, and tendons, leading to the signs and symptoms of type III ...
In fact, there is more collagen in the human body than any other protein. It serves an important role as a major component of connective tissues and keeping skin strong and elastic . The body ...
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