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Mephenesin (), also called myanesin, [1] [2] is a centrally acting muscle relaxant.It can be used as an antidote for strychnine poisoning.Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index.
Tolperisone is a centrally acting skeletal muscle relaxant that acts at the reticular formation in the brainstem [3] by blocking voltage-gated sodium and calcium channels. [ 11 ] [ 12 ] Pharmacokinetics
Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. [5] It is not useful in cerebral palsy. [5] It is taken by mouth. [5] Common side effects include headache, feeling tired, dizziness, and dry mouth. [5]
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Eperisone (formulated as the eperisone hydrochloride salt) is an antispasmodic drug.. Eperisone acts by relaxing both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.
Mephenoxalone (trade names Dorsiflex, Moderamin, Control-OM) is a muscle relaxant [2] and mild anxiolytic. [3] It inhibits neuron transmission, relaxing skeletal muscles by inhibiting the reflex arc. [citation needed] As the effect of muscle relaxation, mephenoxalone affects mental condition, and is also a treatment for nervousness and anxiety.
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Orphenadrine is a skeletal muscle relaxant. [ 1 ] [ 3 ] It is used to relieve pain caused by muscle injuries such as strains and sprains , in combination with rest and physical therapy. [ 3 ] A 2004 review found fair evidence that orphenadrine is effective for acute back or neck pain, but found insufficient evidence to establish the relative ...