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Neuromyelitis optica (NMO) is a particular disease within the NMOSD spectrum. It is characterised by optic neuritis and longitudinally extensive myelitis. In more than 80% of NMO cases, the cause is immunoglobulin G autoantibodies to aquaporin 4 ( anti-AQP4 ), the most abundant water channel protein in the central nervous system.
Uhthoff's phenomenon may affect any person with a demyelinating disease. [1] This is most commonly MS, but it may also occur with neuromyelitis optica spectrum disorder [1] [3] or Guillain-Barré Syndrome. It affects between 60% and 80% of people with MS. [1] [3]
340 Multiple sclerosis; 341 Other demyelinating diseases of central nervous system. 341.0 Neuromyelitis optica; 341.1 Schilder's disease; 341.8 Other; 341.9 Unspecified; 342 Hemiplegia. 342.0 Flaccid hemiplegia; 342.1 Spastic hemiplegia; 342.9 Unspecified; 343 Infantile cerebral palsy. 343.0 Diplegic; 343.1 Hemiplegic; 343.2 Quadriplegic; 343.3 ...
Brain lesions associated with a clinically isolated syndrome may be indicative of several neurological diseases, like multiple sclerosis (MS) or neuromyelitis optica. In order for such a diagnosis , multiple sites in the central nervous system must present lesions, typically over multiple episodes, and for which no other diagnosis is likely.
Standard multiple sclerosis, the most known and extended variant. Devic's disease and neuromyelitis optica (NMO) (sometimes previously called optic-spinal MS) Acute disseminated encephalomyelitis or ADEM, a closely related disorder in which a known virus or vaccine triggers autoimmunity against myelin.
This last requirement makes MS an ill-defined entity, whose borders change every time that a new disease is set apart. Some cases previously considered MS are now considered distinct conditions, like Neuromyelitis optica or antiMOG associated encephalomyelitis. Because of the requirement of distributed lesions, a single lesion (RIS) is not ...
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