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NS1 antigen test (nonstructural protein 1) is a test for dengue, introduced in 2006. It allows rapid detection on the first day of fever, before antibodies appear some 5 or more days later. [1] It has been adopted for use in some 40 nations. The method of detection is through enzyme-linked immunosorbent assay.
The test was once part of the World Health Organization (WHO) algorithm for diagnosis of dengue fever, [3] however it is no longer used in the latest WHO guidance. [4] Studies have shown that the tourniquet test has low predictive value for dengue fever and should be used in conjunction with other tests for a reliable diagnosis. [5] [6] [7] [8]
The Widal test is positive if TO antigen titer is more than 1:160 in an active infection, or if TH antigen titer is more than 1:160 in past infection or in immunized persons. A single Widal test is of little clinical relevance especially in endemic areas such as Indian subcontinent, Africa and South-east Asia.
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The term "breakbone fever" was first applied by physician and United States Founding Father Benjamin Rush, in a 1789 report of the 1780 epidemic in Philadelphia. In the report he uses primarily the more formal term "bilious remitting fever". [46] [47] The term dengue fever came into general use only after 1828. [45]
The term break-bone fever was applied by physician and United States Founding Father Benjamin Rush, in a 1789 report of the 1780 epidemic in Philadelphia, due to the associated muscle and joint pains. In the report title he uses the more formal term "bilious remitting fever". [87] The term dengue fever came into general use only after 1828. [86]
Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. [1] [2] Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, [3] [4] [5] all of which can cause the full spectrum of disease. [1]
Donald Trump’s pick for defense secretary, Pete Hegseth, said gay people should be able to serve in the US military in an apparent shift from his previous stance on the issue.