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Endogenous cardiac stem cells were first discovered in 2003 by Bernardo Nadal-Ginard, Piero Anversa and colleagues [2] [3] in the adult rat heart and since then have been identified and isolated from mouse, dog, porcine and human hearts. [4] [5] The adult heart was previously thought to be a post mitotic organ without any regenerative capability.
Cellular cardiomyoplasty, or cell-based cardiac repair, is a new potential therapeutic modality in which progenitor cells are used to repair regions of damaged or necrotic myocardium. The ability of transplanted progenitor cells to improve function within the failing heart has been shown in experimental animal models and in some human clinical ...
Valve interstitial cells (VIC), cardiac valve interstitial cells, or also known as valvular interstitial cells (VICs), are the most prevalent cells in the heart valve leaflets, which are a type of mesenchymal stem cells (MSCs) and are responsible for maintaining the extracellular matrix that provides the mechanical properties of the heart valve.
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).
Adult stem cells, also called somatic (from Greek σωματικóς, "of the body") stem cells, are stem cells which maintain and repair the tissue in which they are found. [44] There are three known accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, usually from pelvic bones via ...
Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases [4] and conditions such as diabetes and heart disease. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create ...
The sarcoplasmic reticulum is a network of the tubules that extend throughout muscle cells, wrapping around (but not in direct contact with) the myofibrils (contractile units of the cell). Cardiac and skeletal muscle cells contain structures called transverse tubules (T-tubules), which are extensions of the cell membrane that travel into the ...
It covers contemporary and emerging areas in stem cells, including embryonic and adult stem cells, and related lineage and cloning issues. The journal also publishes reviews covering basic, clinical, biotechnology, regulatory, and ethical aspects of stem cell research and applications. [1] The journal got its current name in 2009 from Stem Cell ...
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