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Multiplate multiple electrode aggregometry (MEA) is a test of platelet function in whole blood. [ 1 ] [ 2 ] The test can be used to diagnose platelet disorders, [ 3 ] [ 4 ] [ 5 ] monitor antiplatelet therapy, [ 6 ] and is also investigated as a potential predictor of transfusion requirements and bleeding risk in cardiac surgery.
Aspirin inhibits platelet function via the AA pathway while clopidogrel inhibits platelet function via the ADP pathway; thus, this test can be used to determine the degree to which a patient is anticoagulated due to either medication. In this assay, a standard TEG is run using patient's whole blood.
The PFA-100 (Platelet Function Assay — 100) is a system for analysing platelet function in which citrated whole blood is aspirated through a disposable cartridge containing an aperture within a membrane coated with either collagen and epinephrine or collagen and ADP. These agonists induce platelet adhesion, activation and aggregation, leading ...
These parameters denote the speed at which a solid clot forms and are primarily influenced by platelet function, but to a certain extent especially fibrinogen and coagulation factors contribute. A prolonged CFT (or a lower alpha-angle) is usually caused by poor platelet function, low platelet count, fibrin polymerization disorders or fibrinogen ...
The PFA test result is dependent on platelet function, plasma von Willebrand Factor level, platelet number, and (to some extent) the hematocrit (that is, the percent composition of red blood cells in the sample). The PFA test is initially performed with the Collagen/Epinepherine membrane.
The ristocetin-induced platelet aggregation (RIPA) is an ex vivo assay for live platelet function. It measures platelet aggregation with the help of von Willebrand factor (vWF) and exogenous antibiotic ristocetin added in a graded fashion. [ 1 ]
Bleeding time is a medical test done to assess the function of a person's platelets. It involves making a patient bleed, then timing how long it takes for them to stop bleeding using a stopwatch or other suitable devices. The term template bleeding time is used when the test is performed to standardized parameters.
Numerous medical tests are used to assess the function of the coagulation system: [3] [46] Common: aPTT, PT (also used to determine INR), fibrinogen testing (often by the Clauss fibrinogen assay), [47] platelet count, platelet function testing (often by PFA-100), thrombodynamics test.