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Samandarines are exclusively produced and secreted by the fire salamander through their parotoid glands (20 mg/gland). Samandarin is the main component of these glandular secretions, although the precise ratio of the alkaloids can vary from species to species and individual to individual. [5]
Ergotism (pron. / ˈ ɜːr ɡ ə t ˌ ɪ z ə m / UR-gət-iz-əm) is the effect of long-term ergot poisoning, traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus—from the Latin clava "club" or clavus "nail" and -ceps for "head", i.e. the purple club-headed fungus—that infects rye and other cereals, and more recently by the action of a number of ...
Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
The fire salamander's primary alkaloid toxin, samandarin, causes strong muscle convulsions and hypertension combined with hyperventilation in all vertebrates. Through an analysis of the European fire salamander’s skin secretions, scientists have determined that another alkaloid, such as samandarone, is also released by the salamander. [14]
Symptoms may vary depending on certain factors such as the size and age of the victim. Other than the first, more benign symptoms (such as a tingling or burning sensation in the eyes, mucous membranes, or in exposed wounds), the most frequently described symptoms in the medical literature are : paleness; bradycardia
Salamandridae is a family of salamanders consisting of true salamanders and newts. Salamandrids are distinguished from other salamanders by the lack of rib or costal grooves along the sides of their bodies and by their rough skin. Their skin is very granular because of the number of poison glands. They also lack nasolabial grooves.
The combination fluticasone furoate/umeclidinium bromide/vilanterol product is approved by the US Food and Drug Administration with an indication for the maintenance treatment of a chronic lung problem called chronic obstructive pulmonary disease (COPD) in adults who (1) have already tried fluticasone furoate/vilanterol (brand name Breo Ellipta) but are still experiencing symptoms of airway ...
This crisis may be masked by the concomitant use of atropine along with cholinesterase inhibitor medication in order to prevent side effects. Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium (Tensilon), as it only worsens the paralysis caused by cholinergic crisis ...