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[7] [65] There is also initial evidence that major depression and stress can alter the permeability of the blood-brain barrier, allowing substances which would normally not be able to pass through enter the brain, thereby increasing the ways peripheral inflammation can affect the brain. [65] [79]
For example, when the brain lacks serotonin, a chemical that regulates the brain's functioning, it can lead to depression, appetite changes, aggression, and anxiety. Another cause of mental distress can be exposure to severely distressing life-threatening situations and experiences. A third cause, in very rare cases, can be inheritance.
A 2025 study suggests that depression affects not only mental health but also accelerates the development of chronic physical conditions. [62] Individuals with a history of depression are at a higher risk of developing long-term health issues, including heart disease and diabetes. [63]
Research on the impact of sexual assault on health in women populations find that targets of sexual harassment experience a range of mental health outcomes– including depression, anxiety, fear, guilt, shame, anger, and PTSD– [99] and physical health problems such as headaches, digestive system issues, and sleep disorders. [100]
Physical illnesses, including hypothyroidism and mitochondrial disease, can also trigger depressive symptoms. [5] [6] Neural circuits implicated in depression include those involved in the generation and regulation of emotion, as well as in reward. Abnormalities are commonly found in the lateral prefrontal cortex whose putative function is ...
Physical activity enhances neuroplasticity, which is the way our brains develop, strengthen and adapt the neural connections that promote cognitive health, research has shown. Exercise also ...
Throughout the years, there have been inconsistent links found to certain viral infections, substance misuse, and general physical health that have been false. Adverse experiences affect a person's mental health, including abuse, neglect, bullying, social stress, traumatic events, and other overwhelming life experiences. The specific risks and ...
Along with physical injury, mental health can be affected by an array of various other factors such as serious concussions, body standards, pressure from a highly competitive atmosphere, etc. [15] Studies have shown that collegiate athletes are at a higher risk for problems such as depression, suicidal ideation, alcohol and substance use, and ...
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