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D-Phenylalanine (DPA, D-Phe), sold under the brand names Deprenon, Sabiben, and Sabiden, is an enantiomer of phenylalanine which is described as an antidepressant and is marketed as a prescription drug for medical use in Argentina. [1] [2] The medication has been marketed since at least the 1970s [3] and continued to be available by the 2000s. [1]
D-Phenylalanine is a psychostimulant and selective norepinephrine releasing agent (NRA) or norepinephrine-preferring norepinephrine–dopamine releasing agent (NDRA). [ 1 ] [ 2 ] The EC 50 Tooltip half-maximal effective concentration values of D -phenylalanine for monoamine release are 106 nM for norepinephrine, 1,355 nM for dopamine , and ...
There’s a laundry list of things that men and women experience differently, but new research finds that pain may be yet another one.. The study, which was published in PNAS Nexus on October 14 ...
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Examples include racecadotril, ubenimex (bestatin), RB-101, and D-phenylalanine, as well as the endogenous opioid peptides opiorphin and spinorphin. [1] It also includes RB-3007, Semax and Selank. Analgesic, anticraving, antidepressant, anxiolytic, and antidiarrheal effects are common properties of enkephalinase inhibitors. [1]
Like all protein-rich foods, spirulina contains the essential amino acid phenylalanine (2.6–4.1 g/100 g), [5] which should be avoided by people who have phenylketonuria, a rare genetic disorder that prevents the body from metabolizing phenylalanine, which then builds up in the brain, causing damage. [51]
DA-Phen is a conjugate of dopamine and the amino acid phenylalanine (Phe or Phen). [ 1 ] [ 2 ] It is slowly cleaved by brain enzymes ( t ½ = 460 minutes) to yield free dopamine but is also rapidly hydrolyzed in human blood plasma (t ½ = 28 minutes). [ 2 ]