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Among US military service members vaccinated between December 2002 and March 2003 with Dryvax smallpox vaccine 18 cases of probable myopericarditis were reported, which was an incidence of 7.8 per 100 000 over 30 days. [5] A meta-review from 2022 shows that the overall risk for myopericarditis after receiving a COVID-19 vaccine is low. [6]
Pericarditis is inflammation of the pericardium, the fibrous sac surrounding the heart. [8] Symptoms typically include sudden onset of sharp chest pain, which may also be felt in the shoulders, neck, or back. [1]
Chest pain is one of the common symptoms of acute pericarditis. It is usually of sudden onset, occurring in the anterior chest and often has a sharp quality that worsens with breathing in or coughing, due to inflammation of the pleural surface at the same time.
Myocarditis is defined as inflammation of the myocardium.Myocarditis can progress to inflammatory cardiomyopathy when there are associated ventricular remodeling and cardiac dysfunction due to chronic inflammation.
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There are many causes of eosinophilia that may underlie eosinophilic myocarditis. These causes are classified as primary (i.e. a defect intrinsic to the eosinophil cell line), secondary (induced by an underlying disorder that stimulates the proliferation and activation of eosinophils), or idiopathic (i.e. unknown cause).
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Fibrinous pericarditis is an exudative inflammation.The pericardium is infiltrated by the fibrinous exudate. This consists of fibrin strands and leukocytes.Fibrin describes an amorphous, eosinophilic (pink) network.
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