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Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT 2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also antagonize α 1-adrenergic receptors.
Currently, several different SSRI antidepressants are used to treat depression, anxiety disorders and other conditions. They include: Citalopram (Celexa) is an SSRI used to treat depression. It ...
Vilazodone (Viibryd)While the above SSRI meds all work to increase serotonin levels, there are some differences between them. Sertraline (Zoloft) Paroxetine (Paxil, Pexeva)
No difference risk of suicide attempts was detected between SSRIs versus tricyclic antidepressants. [135] A 2006 review suggests that the widespread use of antidepressants in the new "SSRI-era" appears to have led to a highly significant decline in suicide rates in most countries with traditionally high baseline suicide rates.
For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders.
Medications for Depression: An Overview. Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used ...
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