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Selenium is a component of the amino acids selenocysteine and selenomethionine. In humans, selenium is a trace element nutrient that functions as cofactor for glutathione peroxidases and certain forms of thioredoxin reductase. [1] Selenium-containing proteins are produced from inorganic selenium via the intermediacy of selenophosphate (PSeO 3 3 ...
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
In addition to his aging research, Gladyshev is renowned for his discovery of the full set of 25 human selenoprotein genes, exploring the biological roles of selenium in organisms. His work on selenium metabolism and redox regulation offers insights into essential cellular processes and their implications for aging and cancer.
Selenium is a vital nutrient in animals, [7] including humans. About 25 different selenocysteine-containing selenoproteins have so far been observed in human cells and tissues. [ 8 ] Since lack of selenium deprives the cell of its ability to synthesize selenoproteins, many health effects of low selenium intake are believed to be caused by the ...
Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur. Selenocysteine is present in several enzymes (for example glutathione peroxidases , tetraiodothyronine 5′ deiodinases , thioredoxin reductases , formate dehydrogenases , glycine reductases , selenophosphate synthetase 2 , methionine- R -sulfoxide ...
In humans, selenium is a trace element nutrient that functions as cofactor for reduction of antioxidant enzymes, such as glutathione peroxidases and certain forms of thioredoxin reductase found in animals and some plants (this enzyme occurs in all living organisms, but not all forms of it in plants require selenium).
Selenium, which is an essential element for animals and prokaryotes and is a beneficial element for many plants, is the least-common of all the elements essential to life. [3] [63] Selenium acts as the catalytic center of several antioxidant enzymes, such as glutathione peroxidase, [11] and plays a wide variety of other biological roles.
Selenium deficiency occurs when an organism lacks the required levels of selenium, a critical nutrient in many species.Deficiency, although relatively rare in healthy well-nourished individuals, [1] can have significant negative results, [2] affecting the health of the heart and the nervous system; contributing to depression, anxiety, and dementia; and interfering with reproduction and gestation.