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Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. [1] It is the 3β- sulfate ester and a metabolite of dehydroepiandrosterone (DHEA) and circulates in far greater relative concentrations than DHEA. [ 2 ]
Plasma levels of DHEA in adult men are 10 to 25 nM, in premenopausal women are 5 to 30 nM, and in postmenopausal women are 2 to 20 nM. [25] Conversely, DHEA-S levels are an order of magnitude higher at 1–10 μM. [25] Levels of DHEA and DHEA-S decline to the lower nanomolar and micromolar ranges in men and women aged 60 to 80 years. [25]
In one study, more than half of tumor-affected patients had elevated levels of the androgens androstenedione, dehydroepiandrosterone sulfate, and testosterone. [44] The elevation of androgens caused by adrenocortical carcinomas often causes patients to develop Cushing's syndrome, primary aldosteronism , and hyperandrogenism.
DHEA levels are lower in those with depression, so supplementation may help. A 2005 placebo-controlled study looked at men and women aged 45 to 65 with midlife-onset major or minor depression.
But an imbalance in hormones — like low estrogen levels — can affect many things, from your drive to, well, your hair. ... to dehydroepiandrosterone sulfate (DHEAS) was significantly lower in ...
Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for ...
Levels of DHEA-S, a major adrenal androgen, throughout life in humans. [1]Adrenopause is the decline in secretion and levels of adrenal androgens such as dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) from the zona reticularis of the adrenal glands with age.
The study concluded that elevated levels of two adrenal androgens (DHEA and androstenedione) were found in obese boys compared to boys of a normal weight during the prepubescent stage of life. [8] In addition, future study should be conducted concerning the low levels of androgens found in overweight boys during the postpubescent stage of life ...