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A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.
Since their discovery, anabolic steroids (AAS) have been widely used as performance-enhancing drugs to improve performance in sports, [1] to improve one's physical appearance, as self-medication to recover from injury, and as an anti-aging aid. Use of anabolic steroids for purposes other than treating medical conditions is controversial and, in ...
AAS use can cause harmful changes in cholesterol levels: Some steroids cause an increase ... 1:1–1:8 Drostanolone: 1:3–1:4 ... Support for the latter two theories ...
CDMT was the key steroid administered to approximately ten thousand East German athletes as part of a secret doping program, known as State Plan Topic 14.25, often without them knowing the nature of the "vitamins" they were forced to take. The program remained in place from about 1968 until the collapse of the German Democratic Republic in 1989.
Mesterolone, also known as 1α-methyl-4,5α-dihydrotestosterone (1α-methyl-DHT) or as 1α-methyl-5α-androstan-17β-ol-3-one, is a synthetic androstane steroid and derivative of DHT. [ 19 ] [ 20 ] [ 2 ] It is specifically DHT with a methyl group at the C1α position.
[4] [3] As such, testosterone cypionate and testosterone enanthate are considered to be "functionally interchangeable" as medications. [4] For reference, testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days and requires frequent administration of approximately once per week. [21]
Metandienone, also known as 17α-methyl-δ 1-testosterone or as 17α-methylandrost-1,4-dien-17β-ol-3-one, is a synthetic androstane steroid and a 17α-alkylated derivative of testosterone. [7] It is a modification of testosterone with a methyl group at the C17α position and an additional double bond between the C1 and C2 positions. [ 7 ]
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