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In cats with chronic kidney disease, benazepril has shown to lower blood pressure, including the capillary blood vessel pressure in the filtration system of the kidneys called the glomerulus. At the same time, it increases blood flow through the kidneys and preserves the filtration rate.
Benazepril HCl is a second-generation angiotensin-converting-enzyme (ACE) inhibitor. This medication may be used to treat high blood pressure, as a vasodilator in the treatment of heart failure and as adjunctive treatment of chronic kidney failure.
Benazepril produced a significant reduction in proteinuria, assessed by the urine protein-to-creatinine ratio (UPC, P = .005). This effect of benazepril was present in all subgroups tested, including cats with UPC <0.2, although the effect was largest in cats with higher UPCs.
By preventing protein loss, benazepril plays a crucial role in maintaining kidney health, especially in cats with chronic kidney disease. When it comes to managing hypertension in cats, benazepril is often considered a first-line treatment.
Whilst randomized placebo-controlled studies have demonstrated significant reduction in proteinuria in cats with CKD, to date the only study that evaluated the effect of an angiotensin-converting enzyme inhibitor, benazepril, failed to demonstrate a survival advantage although there was a trend towards improved survival in cats that were more ...
Understanding the diagnostic and therapeutic priorities based on the stage of CKD facilitates appropriate management of dogs and cats with the disease. Here are the International Renal Interest Society Recommendations for treating CKD in dogs and cats.
benazepril decreased proteinuria in cats with CKD. Key words: ACE inhibitor; Appetite; Plasma protein; Proteinuria; Survival time; Urine protein-to-creatinine ratio. Chronic kidney disease (CKD) is one of the main causes of morbidity and mortality in cats.1,2 Studies in animal models and clinical trials in humans