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HepaRG cell line is a human hepatic in vitro line used in liver biology research and for assessing liver pathology, hepatotoxicity, and drug-induced injury. The HepaRG model is considered a surrogate for Primary Human Hepatocytes, which are the most pertinent model to reproduce the human liver functioning as they express 99% of the same genes .
Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
The Comprehensive Cancer Center is one of 51 comprehensive cancer centers in the United States as designated by the National Cancer Institute [3] of the National Institutes of Health. The first cancer research center director was John Ultmann whose specialty was the diagnosis, staging and treatment of Hodgkin's disease and non-Hodgkin's ...
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. [ 7 ] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Northwestern's Cancer Center, founded in 1974, was renamed in 1991, in recognition of a gift from Ann & Robert H. Lurie. [7]In 1996, during a visit to Chicago, Diana, Princess of Wales visited the Lurie Cancer Center to help raise money for cancer research and to benefit a cancer support group.
The hepatocyte plates are one cell thick in mammals and two cells thick in the chicken. Sinusoids display a discontinuous, fenestrated endothelial cell lining. The endothelial cells have no basement membrane and are separated from the hepatocytes by the space of Disse, which drains lymph into the portal tract lymphatics. [citation needed]
The Chicago ENT specialty practice for ear, nose and throat includes services for diagnostic, treatment and surgical intervention for ENT, as well as, allergy/immunology and audiology services. The Strauss Oncology Center at Weiss has a cancer research program that is an accredited through the American College of Surgeons Commission on Cancer. [6]
A prospective study found that increased hepatocellular cancer risk is associated with higher levels of major circulating bile acids that were measured in people several years prior to tumor diagnosis. [104] In another study using a mouse model, it was found that dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. [105]