Search results
Results from the WOW.Com Content Network
The Henderson–Hasselbalch equation was developed by two scientists, Lawrence Joseph Henderson and Karl Albert Hasselbalch. [2] Lawrence Joseph Henderson was a biological chemist and Karl Albert Hasselbalch was a physiologist who studied pH. [2] [3] In 1908, Lawrence Joseph Henderson [4] derived an equation to calculate the hydrogen ion ...
As calculated by the Henderson–Hasselbalch equation, in order to maintain a normal pH of 7.4 in the blood (whereby the pK a of carbonic acid is 6.1 at physiological temperature), a 20:1 ratio of bicarbonate to carbonic acid must constantly be maintained; this homeostasis is mainly mediated by pH sensors in the medulla oblongata of the brain ...
Karl Albert Hasselbalch (Danish pronunciation: [ˈkʰɑˀl ˈælˀpɐt ˈhæsl̩ˌpælˀk]; 1 November 1874 – 19 September 1962) was a Danish physician and chemist known for his work on the Henderson–Hasselbalch equation.
This is the Henderson–Hasselbalch equation, from which the following conclusions can be drawn. At half-neutralization the ratio [A −] / [HA] = 1; since log(1) = 0, the pH at half-neutralization is numerically equal to pK a. Conversely, when pH = pK a, the concentration of HA is equal to the concentration of A −.
Hence, the pK of each buffer will dictate the ratio of the concentrations of its base and weak acid forms at the given pH, in accordance with the Henderson-Hasselbalch equation. Any condition that changes the balance of one of the buffer systems, also changes the balance of all the others because the buffer systems actually buffer one another ...
This is why weak acids are better absorbed from the stomach and weak bases from intestine where the pH is alkaline. When pH of a solution is equal to pKa of dissolved drug, then 50% of the drug is ionized, another 50% is unionized. This is described by the Henderson-Hasselbalch equation. [citation needed]
Speciation of ions refers to the changing concentration of varying forms of an ion as the pH of the solution changes. [1]The ratio of acid, AH and conjugate base, A −, concentrations varies as the difference between the pH and the pK a varies, in accordance with the Henderson-Hasselbalch equation.
Lawrence Henderson was born in Lynn, Massachusetts the son of a business man Joseph Henderson and his wife. He entered Harvard at the age of 16 in 1894. His father was a ship chandler whose principal business was located in nearby Salem, but who also conducted business in Saint Pierre and Miquelon, a French Overseas collectivity off the coast of Canada.