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Poisoning can occur if pyrethroid containing flea treatment products, which are intended for dogs, are used on cats. The livers of cats detoxify pyrethroids via glucuronidation more poorly than dogs, which is the cause of this difference. [15] Aside from cats, pyrethroids are typically not toxic to mammals or birds. [16]
Pyrethrins and Pyrethroids Fact Sheet - National Pesticide Information Center; Pyrethrins and pyrethroids on the EXTOXNET; Pyrethrin and Permethrin Toxicity in Dogs and Cats; Wagner, S. L. (2000). "Fatal asthma in a child after use of an animal shampoo containing pyrethrin". The Western Journal of Medicine. 173 (2): 86– 7. doi:10.1136/ewjm ...
Cyfluthrin is a pyrethroid insecticide and common household pesticide. It is a complex organic compound and the commercial product is sold as a mixture of isomers.Like most pyrethroids (MoA 3a), [1] it is highly toxic to fish and invertebrates, but it is far less toxic to humans. [2]
Exposure to pyrethroid-derived drugs such as permethrin requires treatment by a veterinarian, otherwise the poisoning is often fatal. [53] [54] This intolerance is due to a defect in glucuronosyltransferase, a common detoxification enzyme in other mammals, that also makes the cat intolerant to paracetamol (acetaminophen). [55]
Phenothrin, also called sumithrin and d-phenothrin, [2] is a synthetic pyrethroid that kills adult fleas and ticks.It has also been used to kill head lice in humans. d-Phenothrin is used as a component of aerosol insecticides for domestic use.
Pyrethroids may adversely affect the central nervous system. Human volunteers given dermal doses of 130 μg/cm 2 on the earlobe experienced local tingling and burning sensations. One man died after eating a meal cooked in a 10% cypermethrin/oil mix that was mistakenly used for cooking oil. [ 3 ]
Raid derivatives aimed at particular invertebrate species can contain other active agents such as the more toxic cyfluthrin which is also a pyrethroid. [2] As of 2019 Raid Ant & Roach Killer contains pyrethroids, imiprothrin , and cypermethrin ; [ 3 ] other products contain tetramethrin and prallethrin as active ingredients. [ 4 ]
Cyhalothrin (ISO common name [3]) is an organic compound that, in specific isomeric forms, is used as a pesticide. [4] It is a pyrethroid, a class of synthetic insecticides that mimic the structure and properties of the naturally occurring insecticide pyrethrin which is present in the flowers of Chrysanthemum cinerariifolium.