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Leptospirosis is a blood infection caused by the bacteria Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild (headaches, muscle pains, and fevers) to severe (bleeding in the lungs or meningitis). [5]
The treatment for rat-bite fever is consistent regardless of the bacterial cause. Intravenous penicillin is traditionally the treatment for uncomplicated cases of rat-bite fever, however intravenous ceftriaxone may also be used. The dose and duration of antibiotic treatment depends on the clinical presentation and severity.
Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. It should be contrasted with pre-exposure prophylaxis , which is used before the patient has been exposed to the infective agent.
Doxycycline is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. [1] It is used to treat bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis. [1] It is also used to prevent malaria.
Doxycycline is also used as a prophylactic treatment for infection by Bacillus anthracis and is effective against Yersinia pestis, the infectious agent of bubonic plague. It is also used for malaria treatment and prophylaxis, as well as treating elephantitis filariasis. [10]
Leptospirosis in canines can be divided into the four categories of reproductive, icteric, hemorrhagic, and uremic. Reproductive leptospirosis results in the premature birth of offspring or abortion, and uremic leptospirosis is referred to as Stuttgart disease. [32] L. interrogans triggers a highly inflammatory response in infected dogs.
Also, the virulence factors on the flagella of pathogenic leptospires have thought to be involved in the overall infection. [15] Leptospira noguchii specifically creates a median lethal dose (LD 50) of three to 100 leptospires. [15] L. noguchii also uses the Lsa24 protein to avoid the immune system of the host and antibacterials by binding to ...
Penicillin, doxycycline, and sulfonamides: No Adenoviridae: Adenovirus infection: Antigen detection, polymerase chain reaction assay, virus isolation, and serology: Most infections are mild and require no therapy or only symptomatic treatment. Under research [1] Trypanosoma brucei: African sleeping sickness (African trypanosomiasis)
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