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Leptospirosis is a blood infection caused by the bacteria Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild (headaches, muscle pains, and fevers) to severe (bleeding in the lungs or meningitis). [5]
The icteric phase, or phase two, includes more severe symptoms including hemorrhages and renal tubular failure. [5] The main ways for testing for bacteria and diagnosing infections include the microscopic agglutination test (MAT) and PCR. [6] Leptospirosis is treated in humans by the antibiotics penicillin and doxycycline. [7] [8]
Symptoms do not manifest for two to four weeks after exposure to the organism, and the wound through which it entered exhibits slow healing and marked inflammation. The fever lasts longer and is recurring, for months in some cases. Rectal pain and gastrointestinal symptoms are less severe or are absent. Penicillin is the most common treatment.
Also, the virulence factors on the flagella of pathogenic leptospires have thought to be involved in the overall infection. [15] Leptospira noguchii specifically creates a median lethal dose (LD 50) of three to 100 leptospires. [15] L. noguchii also uses the Lsa24 protein to avoid the immune system of the host and antibacterials by binding to ...
Health care providers should consider prescribing a commonly used antibiotic to certain people as a way to prevent chlamydia, gonorrhea and syphilis infections, according to a draft recommendation ...
Doxycycline is a broad-spectrum antibiotic that is employed in the treatment of numerous bacterial infections. It is effective against bacteria such as Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae. Additionally, doxycycline is used in the prevention and treatment of serious conditions like anthrax ...
The reaction is also seen in the other diseases caused by spirochetes: Lyme disease, relapsing fever, and leptospirosis. [4] There have been case reports of the Jarisch–Herxheimer reaction accompanying treatment of other infections, including Q fever, bartonellosis, brucellosis, trichinellosis, and African trypanosomiasis. [3]
Penicillin, doxycycline, and sulfonamides: No Adenoviridae: Adenovirus infection: Antigen detection, polymerase chain reaction assay, virus isolation, and serology: Most infections are mild and require no therapy or only symptomatic treatment. Under research [1] Trypanosoma brucei: African sleeping sickness (African trypanosomiasis)
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