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A hierarchy of evidence, comprising levels of evidence (LOEs), that is, evidence levels (ELs), is a heuristic used to rank the relative strength of results obtained from experimental research, especially medical research. There is broad agreement on the relative strength of large-scale, epidemiological studies.
Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. [1] It is used to treat chronic obstructive pulmonary disease (COPD) and asthma . [ 2 ]
Level II-1: Evidence obtained from well-designed controlled trials without randomization. Level II-2: Evidence obtained from well-designed cohort studies or case-control studies, preferably from more than one center or research group. Level II-3: Evidence obtained from multiple time series designs with or without the intervention. Dramatic ...
Umbrella reviews are among the highest levels of evidence currently available in medicine. [ 2 ] By summarizing information from multiple overview articles, umbrella reviews make it easier to review the evidence and allow for comparison of results between each of the individual reviews. [ 1 ]
Here are links to possibly useful sources of information about Theophylline. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .
Taliercio's is crafting fried ravioli Christmas trees, trimmed with kale, cherry tomatoes and around 50 of the ricotta-stuffed pasta circles.
Describe the level of evidence of a given source; Avoid over-emphasizing single studies, particularly in vitro or animal studies; Use up-to-date evidence; Remember that even clinical trials in humans have phases. Only about 18% of new drug candidates pass Phase II and only about 50% of those that make it to Phase III are approved.
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