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[15] [16] This disease is centered on the glucose-6-phosphate protein. This protein can be found in the secretion of some cancer cells. [17] PHI is the result of a dimeric enzyme that catalyses the reversible interconversion of fructose-6-phosphate and gluose-6-phosphate. [15] PHI is a very rare disease with only 50 cases reported in literature ...
Ribose-5-phosphate isomerase deficiency (RPID) is a rare human disorder caused by mutations in ribose-5-phosphate isomerase, an enzyme of the pentose phosphate pathway.With only four known cases – all diagnosed between 1984 and 2019 – RPI deficiency is the second rarest disease, with Fields condition being the rarest, affecting two known individuals, Catherine and Kirstie Fields.
Triosephosphate isomerase deficiency is a rare autosomal recessive [2] metabolic disorder which was initially described in 1965. [ 3 ] It is a unique glycolytic enzymopathy that is characterized by chronic haemolytic anaemia , cardiomyopathy , susceptibility to infections, severe neurological dysfunction, and, in most cases, death in early ...
Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme ( EC 5.3.1.9) that in humans is encoded by the GPI gene on chromosome 19. [4] This gene encodes a member of the glucose phosphate isomerase protein family.
Triose phosphate isomerase is a highly efficient enzyme, performing the reaction billions of times faster than it would occur naturally in solution. The reaction is so efficient that it is said to be catalytically perfect : It is limited only by the rate the substrate can diffuse into and out of the enzyme's active site.
Ribose-5-phosphate isomerase (Rpi) encoded by the RPIA gene is an enzyme (EC 5.3.1.6) that catalyzes the conversion between ribose-5-phosphate (R5P) and ribulose-5-phosphate (Ru5P). It is a member of a larger class of isomerases which catalyze the interconversion of chemical isomers (in this case structural isomers of pentose ).
The isomerase has now been observed in nearly a hundred species of bacteria. [2] Xylose-isomerases are also commonly called glucose isomerase or fructose isomerases due to their ability to interconvert glucose and fructose. The systematic name of this enzyme class is α-D-xylopyranose aldose-ketose-isomerase. Other names in common use include D ...
The TIM barrel (triose-phosphate isomerase), also known as an alpha/beta barrel, [1]: 252 is a conserved protein fold consisting of eight alpha helices (α-helices) and eight parallel beta strands (β-strands) that alternate along the peptide backbone. [2] The structure is named after triose-phosphate isomerase, a conserved metabolic enzyme. [3]