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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± 22: 13.8 ± 4.6: CB 2 (12x) JWH-016: Naphthoylindole: 22 ± 1.5: 4.3 ± 1.6: CB 2 (5.1x) JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019 ...
JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus, have been all banned in Latvia since 2005. [135] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned substances used in Spice and similar preparations.
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
Chemical structure of JWH-018, a simple naphthoylindole. Naphthoylindoles are a class of synthetic cannabinoids. [1] Pharmacology.
On the 19th of January 2009, the University of Freiburg in Germany announced that an analog of CP 47,497 is the main active ingredient in the herbal "incense" product Spice, specifically the 1,1-dimethyloctyl homologue of CP 47,497.
JWH cannabinoids are those discovered by John W. Huffman and his team. Pages in category "JWH cannabinoids" The following 56 pages are in this category, out of 56 total.
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. It is the N -hexyl homolog of the more common synthetic cannabinoid compound JWH-018 .