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Although it is possible for men to father children into old age, the genetic quality of sperm, as well as its volume and motility, all typically decrease with age. [2] Advancing paternal age has been implicated in several possible health effects. One particularly well-studied connection is the link between advancing age and autism. For example ...
Some studies showed that isoflavone supplementation had a positive effect on sperm concentration, count, or motility, and increased ejaculate volume. [ 41 ] [ 42 ] Sperm count decline and increasing rate of testicular cancers in the West may be linked to a higher presence of isoflavone phytoestrogens in the diet while in utero, but such a link ...
Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. [2] [3] Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.
Although isoflavones and closely-related phytoestrogens are sold as dietary supplements, there is little scientific evidence for either the safety of long-term supplementation or of health benefits from these compounds. [1] Some studies indicate that isoflavone supplementation may help lower the risk of hormone-related cancers. [1] [4]
In vitro studies have shown genistein to induce apoptosis of testicular cells at certain levels, thus raising concerns about effects it could have on male fertility; [57] however, one study found that isoflavones had "no observable effect on endocrine measurements, testicular volume or semen parameters over the study period." in healthy males ...
The World Health Organization published its first laboratory manual for semen analysis in 1980, which sets global standard parameters for the measurement of sperm quality and normality. [20] Limited research in the 1980s found the first indications behind the decline, with links to environmental-toxin exposure and excessive heat in the genital ...
Isoflavonoids and their derivatives are sometimes referred to as phytoestrogens, as many isoflavonoid compounds have biological effects via the estrogen receptor. Medically, isoflavonoids and related compounds have been used in many dietary supplements but the medical and scientific community [ who? ] is generally skeptical of their use.
Sperm motility increases from puberty through one's mid-thirties. Research shows that from the age of 36 onwards, sperm motility decreases from 40% Grade A & B to 31% in one's 50s. The effects of aging on semen quality is summarized below based on a study of 1,219 subjects: [7]