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Skeletal muscle (commonly referred to as muscle) is one of the three types of vertebrate muscle tissue, the other being cardiac muscle and smooth muscle. They are part of the voluntary muscular system [ 1 ] and typically are attached by tendons to bones of a skeleton. [ 2 ][ 3 ] The skeletal muscle cells are much longer than in the other types ...
The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. [ 2 ] In eukaryotes, it extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms. It is composed of three main components ...
As suggested by the first model, all IF proteins appear to have a central alpha-helical rod domain that is composed of four alpha-helical segments (named as 1A, 1B, 2A and 2B) separated by three linker regions. [9] [10] The central building block of an intermediate filament is a pair of two intertwined proteins that is called a coiled-coil ...
A muscle cell, also known as a myocyte, is a mature contractile cell in the muscle of an animal. [ 1 ] In humans and other vertebrates there are three types: skeletal, smooth, and cardiac (cardiomyocytes). [ 2 ] A skeletal muscle cell is long and threadlike with many nuclei and is called a muscle fiber. [ 3 ]
The sliding filament theory explains the mechanism of muscle contraction based on muscle proteins that slide past each other to generate movement. [1] According to the sliding filament theory, the myosin (thick filaments) of muscle fibers slide past the actin (thin filaments) during muscle contraction, while the two groups of filaments remain ...
Upon activation by its ligand agrin, MuSK signals via two proteins called "Dok-7" and "rapsyn", to induce "clustering" of acetylcholine receptors. [13] ACh release by developing motor neurons produces postsynaptic potentials in the muscle cell that positively reinforces the localization and stabilization of the developing neuromuscular junction ...
Myosins (/ ˈmaɪəsɪn, - oʊ -/ [ 1 ][ 2 ]) are a family of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP -dependent and responsible for actin -based motility. The first myosin (M2) to be discovered was in 1864 by Wilhelm Kühne.
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils.It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm.