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Cat supplements are available that contain l-theanine and l-tryptophan. Both of these increase the monoamine neurotransmitter serotonin which acts like a hormone in the cat’s brain.
In addition, calming supplements such as tryptophan or alpha-casozepine can also be added to food to improve mood and relaxation. [ 20 ] [ 22 ] Oral supplements to reinstate the protective glycosaminoglycan (GAG) layer of the bladder (often deficient in cats suffering from FIC) may also be considered.
5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
Tryptophan ball and stick model spinning. Tryptophan (symbol Trp or W) [3] is an α-amino acid that is used in the biosynthesis of proteins.Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent.
Biosynthesis of niacin occurs by metabolism of tryptophan via the kynurenine pathway to quinolinic acid, the niacin precursor. However, cats have a high activity of picolinic acid carboxylase, which converts one of the intermediates to picolinic acid instead of quinolinic acid. As a result, niacin can become deficient and require supplementation.
According to AAFCO Dog and Cat Food Nutrient Profiles (2014), the minimum amount of AA for the growth and reproduction in cat food is 0.02% on a dry matter basis or 0.05g per 1000 kcal ME per day. [9] The minimum of adult maintenance in cats is 0.02% on a dry matter basis or 0.05g per 1000 kcal ME per day. [9]
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