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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
IBM sold a mouse with a pointing stick in the location where a scroll wheel is common now. A pointing stick on a mid-1990s-era Toshiba laptop. The two buttons below the keyboard act as a computer mouse: the top button is used for left-clicking while the bottom button is used for right-clicking.
SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
A computer mouse (plural mice, also mouses) [nb 1] is a hand-held pointing device that detects two-dimensional motion relative to a surface. This motion is typically translated into the motion of the pointer (called a cursor) on a display, which allows a smooth control of the graphical user interface of a computer. The first public ...
Closeup of a touchpad on an Acer CB5-311 laptop Closeup of a touchpad on a MacBook 2015 laptop. A touchpad or trackpad is a type of pointing device.Its largest component is a tactile sensor: an electronic device with a flat surface, that detects the motion and position of a user's fingers, and translates them to 2D motion, to control a pointer in a graphical user interface on a computer screen.
Leonard P. Guarente is recognized as the leading proponent of the hypothesis that caloric restriction slows aging by activation of Sirtuins. [citation needed]STACs have been discovered by Konrad Howitz of Biomol Inc and biologist David Sinclair.
4837 18113 Ensembl ENSG00000166741 ENSMUSG00000032271 UniProt P40261 O55239 RefSeq (mRNA) NM_006169 NM_001311062 NM_010924 RefSeq (protein) NP_006160 NP_001358974 NP_001358975 NP_001358976 NP_001297991 NP_035054 Location (UCSC) Chr 11: 114.26 – 114.31 Mb Chr 9: 48.5 – 48.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nicotinamide N-methyltransferase (NNMT) is an enzyme that ...
A computer mouse Touchpad and a pointing stick on an IBM notebook Trackpoint An elder 3D mouse 3D pointing device. A pointing device is a human interface device that allows a user to input spatial (i.e., continuous and multi-dimensional) data to a computer.