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  2. Hyperammonemia - Wikipedia

    en.wikipedia.org/wiki/Hyperammonemia

    Hyperammonemia, or high ammonia levels, is a metabolic disturbance characterised by an excess of ammonia in the blood. Severe hyperammonemia is a dangerous condition that may lead to brain injury and death. It may be primary or secondary. Ammonia is a substance that contains nitrogen. It is a product of the catabolism of protein.

  3. Hepatic encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Hepatic_encephalopathy

    To make the distinction, abnormal liver function tests and/or ultrasound suggesting liver disease are required, and ideally a liver biopsy. [ 4 ] [ 9 ] The symptoms of hepatic encephalopathy may also arise from other conditions, such as bleeding in the brain and seizures (both of which are more common in chronic liver disease).

  4. Pyruvate carboxylase deficiency - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_carboxylase...

    Affected infants have severe lactic acidosis, a build-up of ammonia in the blood (hyperammonemia), and liver failure. They experience neurological problems including weak muscle tone , abnormal movements, seizures, and coma. Infants with this form of the condition usually survive for less than 3 months after birth.

  5. Metabolic dysfunction–associated steatotic liver disease

    en.wikipedia.org/wiki/Metabolic_dysfunction...

    Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), [a] is a type of chronic liver disease.This condition is diagnosed when there is excessive fat build-up in the liver (hepatic steatosis), and at least one metabolic risk factor.

  6. Protein toxicity - Wikipedia

    en.wikipedia.org/wiki/Protein_toxicity

    Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.

  7. Cirrhosis - Wikipedia

    en.wikipedia.org/wiki/Cirrhosis

    Hepatic encephalopathy (HE) occurs when ammonia and related substances build up in the blood. [44] This build-up affects brain function when they are not cleared from the blood by the liver. Symptoms can include unresponsiveness, forgetfulness, trouble concentrating, changes in sleep habits, or psychosis.

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