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Clemastine, also known as meclastin, is a first-generation H1 histamine antagonist (antihistamine) with anticholinergic properties (drying) and sedative side effects. [1] Like all first-generation antihistamines, it is sedating. [2] [3] Patented in 1960, it came into medical use in 1967. [4]
Side effects include skin irritation, sun sensitivity, allergic reactions, and skin discoloration. [5] It is unclear if use during pregnancy is safe for the baby and use during breastfeeding is not typically recommended. [11] The exact mechanism of action is unknown. [12]
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Side effects of doxylamine include dizziness, drowsiness, and dry mouth, among others. [4] Doxylamine is a potent anticholinergic and has a side-effect profile common to such drugs, including blurred vision, dry mouth, constipation, muscle incoordination, urinary retention, mental confusion, and delirium. [18] [7]
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Common side effects include nausea, pain at the site of injection, and headache. [2] It may also cause a temporary increase in blood pressure and decrease in heart rate after each dose, and darkening of the gums, face, and breasts. [4] The medication is a peptide and acts by activating the melanocortin receptors. [1] [5]
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Common side effects when applied as a cream include rash, redness, and burning. [4] Side effects of the injectable form include bone marrow suppression, vomiting, and seizures. [5] It is unclear if it is safe to use during pregnancy or breastfeeding. [5] It is recommended typically for children over the age of 12. [5]