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Individuals with Addison's disease have more than a doubled mortality rate. [37] Furthermore, individuals with Addison's disease and diabetes mellitus have an almost four-fold increase in mortality compared to individuals with only diabetes. [38] The risk ratio for cause mortality in males and females is 2.19 and 2.86, respectively. [37]
Most people with primary Addison's disease have darkening (hyperpigmentation) of the skin, including areas not exposed to the sun; characteristic sites are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa), new scars become hyperpigmented, whereas older ones do not darken.
For example, Addison's disease causes hyperpigmentation in the mouth and may be noticed during an exam followed alongside other systemic symptoms. An oral biopsy alongside other relevant tests (i.e. bloods) should be taken and confirmed for diagnosis for any type of oral melanosis which you suspect to be caused by an underlying disease.
"Hyperpigmentation just means darkening of the skin," says Dr. Dowling. "So basically, 'hyperpigmentation' is an umbrella term for lots of different conditions that cause hyperpigmentation ...
Addison’s disease is an autoimmune condition — affecting about one in 100,000 people — in which the body attacks its organs, specifically the adrenal glands. It’s also called primary ...
Say goodbye to those pesky dark spots.
Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [ 2 ] such as the posterior and lateral folds of the neck , the armpits , groin , navel , forehead and other areas.
Melasma (a type of hyperpigmentation that causes dark patches on the skin due to hormones) specifically effects five million people in the United States alone, according to the Journal of ...