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Nerve allografts bring a possible solution for these problems. Because allografts are human nerves, processed in such a way that the immune response against the transplant is not provoked, the procedure differs little from the autograft-procedure except for the fact that there is no need to create a 'donorplace' defect.
A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve injuries.
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An action potential (or nerve impulse) is a transient alteration of the transmembrane voltage (or membrane potential) across the membrane in an excitable cell generated by the activity of voltage-gated ion channels embedded in the membrane. The best known action potentials are pulse-like waves that travel along the axons of neurons.
Axogen is a developer of surgical solutions, including human tissue grafts, based in Alachua, Florida. [1] Axogen products are designed to remedy peripheral nerve damage. [2] [3] [4] In 2013 the company raised $18 million in its initial public offering (IPO). [5]
The transplant is called an allograft, allogeneic transplant, or homograft. Most human tissue and organ transplants are allografts. It is contrasted with autotransplantation (from one part of the body to another in the same person), syngenic transplantation of isografts (grafts transplanted between two genetically identical individuals) and ...
An orthopedic surgeon replaces the injured ligament with either a hamstring tendon from the patient [6] or from a allograft tendon from a cadaver [8] The surgeon uses an arthroscope to view the interior of the knee, and the reconstruction itself is performed with two small incisions. Initial surgery takes approximately one hour, and the patient ...
Nerve growth factor (NGF) typically has a low level of expression in nerves that are healthy and not growing or developing, but in response to nerve injury NGF expression increases in Schwann cells. This is a mechanism to increase growth and proliferation of Schwann cells at the distal stump in order to prepare for reception of the regenerating ...