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The gastrointestinal wall of the gastrointestinal tract is made up of four layers of specialised tissue. From the inner cavity of the gut (the lumen) outwards, these are the mucosa, the submucosa, the muscular layer and the serosa or adventitia.
Diagram of the alkaline mucous layer in the stomach with mucosal defense mechanisms. The gastric mucosa is the mucous membrane layer of the stomach, which contains the gastric pits, to which the gastric glands empty. In humans, it is about one mm thick, and its surface is smooth, soft, and velvety.
This allows the stomach to expand, therefore increasing the volume of the stomach without increasing pressure. [2] They also provide the stomach with an increased surface area for nutrient absorption during digestion. [2] Gastric folds may be seen during esophagogastroduodenoscopy or in radiological studies. [3] [4]
Rugae folds behind the anterior teeth in the hard palate of the mouth. In anatomy, rugae (sg.: ruga) are a series of ridges produced by folding of the wall of an organ. [1]In general, rugae are a biological feature found in many organisms, serving purposes such as increasing surface area, flexibility, or structural support.
Gastric pits are indentations in the stomach which denote entrances to 3-5 tubular gastric glands. [ 1 ] [ 2 ] They are deeper in the pylorus than they are in the other parts of the stomach. The human stomach has several million of these pits which dot the surface of the lining epithelium .
Gastric chief cells are generally located deep in the mucosal layer of the stomach lining, in the fundus and body of the stomach. [2] [3] Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic activity from the vagus nerve and acidic condition in the stomach.
Histology image: 100_04 at the University of Oklahoma Health Sciences Center - "Esophageal-stomach junction" Histology image: 11103loa – Histology Learning System at Boston University - "Digestive System: Alimentary Canal: esophageal/stomach junction"
Anatomy photo:37:07-0100 at the SUNY Downstate Medical Center; Anatomy photo:38:st-0301 at the SUNY Downstate Medical Center; Anatomy figure: 38:03-04 at Human Anatomy Online, SUNY Downstate Medical Center; Diagram at Tn.edu Archived 2007-02-04 at the Wayback Machine; Photo of model at Waynesburg College digirep/greateromentum