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Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.
Olmesartan, sold under the brand name Benicar among others, is a medication used to treat high blood pressure (hypertension). [ 1 ] [ 2 ] It is taken orally (swallowed by mouth). [ 2 ] Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine . [ 2 ]
However, AT 1 affinity vs AT 2 is not a meaningful indicator of blood pressure response. [38] Losartan – 1000-fold [citation needed] Telmisartan – 3000-fold [citation needed] Irbesartan – 8500-fold [citation needed] Candesartan – greater than 10000-fold [citation needed] Olmesartan – 12500-fold [citation needed]
Azilsartan, candesartan, eprosartan, irbesartan, olmesartan, telmisartan, valsartan; ARBs are generally well-tolerated, in which they are less likely to cause cough or angioedema compared to ACEI. Common side effects include hypotension, renal insufficiency, and hyperkalemia. [7]
Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [ 3 ] [ 6 ] It is a reasonable initial treatment for high blood pressure. [ 6 ]
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A new pill combining low doses of three different anti-hypertensive medications surpassed the standard care for high blood pressure using one anti-hypertensive drug, a new study showed.
Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs).
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