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Atomoxetine is approved for use in children, adolescents, and adults. [5] However, its efficacy has not been studied in children under six years old. [8] One of the primary differences with the standard stimulant treatments for ADHD is that it has little known abuse potential. [8]
Atomoxetine reaches C max 1 to 2 hours after administration. The bioavailability of atomoxetine after oral administration is 63-94%, it is dependent on individual differences in the first-pass metabolism. [18] Atomoxetine is widely distributed and is highly (98%) bound to plasma proteins, mainly albumin.
The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. It is related in chemical structure to venlafaxine. Due to being an opioid, there is risk of abuse and addiction, but it does have less abuse potential, respiratory depression, and constipation compared to other opioids (hydrocodone, oxycodone ...
There are other trade name medications like Strattera, made from atomoxetine, and Qelbree, made from viloxazine, that are not controlled substances and work differently than Adderall and Concerta ...
More specifically, it looked at the effect of methylphenidate (brand names Ritalin, Concerta), a stimulant, and atomoxetine (Strattera), a non-stimulant, on the brain.
The article says that "Unlike stimulant medications, atomoxetine does not have abuse liability or the potential to cause withdrawal effects on abrupt discontinuation." Even though there are a number of anecdotes online about people experiencing withdrawal effects from tapering to a lower amount of atomoxetine (including but not limited to brain ...
Unlike stimulant medications, guanfacine is regarded as having no abuse potential, and may even be used to reduce abuse of drugs including nicotine and cocaine. [17] It is also FDA approved to treat high blood pressure. [7]
She says it's impossible to predict who may be susceptible to abuse the drug, but a history of addiction to other drugs may be a risk factor. "Patients should be counseled on this potential side ...