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Most cell types in loose connective tissue are transient wandering cells that migrate from local blood vessels in response to specific stimuli. Loose connective tissue, therefore, is a site of inflammatory and immune reactions. In areas of the body where foreign substances are continually present, large populations of immune cells are maintained.
Dense connective tissue also known as fibrous tissue [8] is subdivided into dense regular and dense irregular connective tissue. [9] Dense regular connective tissue, found in structures such as tendons and ligaments , is characterized by collagen fibers arranged in an orderly parallel fashion, giving it tensile strength in one direction.
Histology of a synovial membrane. H&E stain. The synovial membrane is variable but often has two layers: [4] The outer layer, or subintima, can be of almost any type of connective tissue – fibrous (dense collagenous type), adipose (fatty; e.g. in intra-articular fat pads) or areolar (loose collagenous type).
Loose connective tissue is characterized by few fibers and cells, and a relatively large amount of ground substance. Dense connective tissue has a smaller amount of ground substance compared to the fibrous material. [2] The meaning of the term has evolved over time. [5]
Tendon cells synthesize the tendon's extracellular matrix, which abounds with densely-packed collagen fibers. The collagen fibers run parallel to each other and are grouped into fascicles. Each fascicle is bound by an endotendineum, which is a delicate loose connective tissue containing thin collagen fibrils [4] [5] and elastic fibers. [6]
It consists mainly of loose areolar and fatty adipose connective tissue and is the layer that primarily determines the shape of a body. [medical citation needed] In addition to its subcutaneous presence, superficial fascia surrounds organs, glands and neurovascular bundles, and fills otherwise empty space at many other locations.
Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. [2] In addition, the sclera contains dense connective tissue [3]
Endomysium combines with perimysium and epimysium to create the collagen fibers of tendons, providing the tissue connection between muscles and bones by indirect attachment. [4] It connects with perimysium using intermittent perimysial junction plates. [5] Collagen is the major protein that composes connective tissues like endomysium. [6]
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