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In June 2010, denosumab was approved by the FDA for use in postmenopausal women with risk of osteoporosis [31] under the brand name Prolia, [32] and in November 2010, as Xgeva for the prevention of skeleton-related events in people with bone metastases from solid tumors. [33] Denosumab is the first RANKL inhibitor to be approved by the FDA. [31]
Denosumab is an FDA-approved fully human monoclonal antibody to RANKL and during pre-clinical trials was first used to treat postmenopausal patients suffering with osteoporosis (PMO). [ 21 ] [ 22 ] In denosumab's third stage of the FDA's clinical trial, it was shown to: (1) decrease bone turnover, (2) reduce fractures in the PMO population, and ...
The drug denosumab acts to raise bone mineral density and reduce fracture rates in many patient sub-groups by inhibiting RANKL. RANKL acts through its receptor RANK , which in turn promotes NF-κB, [ 114 ] RANKL normally works by enabling the differentiation of osteoclasts from monocytes.
7132 21937 Ensembl ENSG00000067182 ENSMUSG00000030341 UniProt P19438 P25118 RefSeq (mRNA) NM_001065 NM_001346091 NM_001346092 NM_011609 RefSeq (protein) NP_001056 NP_001333020 NP_001333021 NP_035739 Location (UCSC) Chr 12: 6.33 – 6.34 Mb Chr 6: 125.33 – 125.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis ...
SERMs are used for various estrogen-related diseases, including treatment of ovulatory dysfunction in the management of infertility treatment, prevention of postmenopausal osteoporosis, treatment and risk reduction of breast cancer, [4] and treatment of dyspareunia due to menopause.
The NIBSC began work in May 1972. The National Biological Standards Board was formed in 1975 at the NIMR in Mill Hill.A site was selected and the new £25m building opened in 1987, although it was officially opened in 1988.
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [4]
The term "fine chemicals" was in use as early as 1908. [1] The emergence of the fine chemical industry as a distinct entity dates to the late 1970s, when the overwhelming success of the histamine H 2 receptor antagonists Tagamet (cimetidine) and Zantac (ranitidine hydrochloride) created a strong demand for advanced organic chemicals used in their manufacture.