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Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances which undergo alpha decay to treat diseased tissue at close proximity. [1] It has the potential to provide highly targeted treatment, especially to microscopic tumour cells.
Alpha radiation is a nuclear phenomenon in which a heavy radionuclide emits an energetic alpha particle (consisting of two protons and two neutrons) and transmutes to a different radionuclide. The emitted alpha particle has a range in tissue of only 40-90 microns, which minimizes collateral damage when used for treatment purposes.
Radioimmunotherapy (RIT) uses an antibody labeled with a radionuclide to deliver cytotoxic radiation to a target cell. [1] It is a form of unsealed source radiotherapy.In cancer therapy, an antibody with specificity for a tumor-associated antigen is used to deliver a lethal dose of radiation to the tumor cells.
The first patient did remarkably well and survived for over 4 years after treatment, but the second died within a month of cardiac complications. [61] Clearly, this is a very challenging approach for the treatment of hepatic metastases, and it is unlikely that it will ever be widely used.
Most men should start getting screened when they reach 50, and Black men, people with a family history of prostate cancer, and others with a higher risk should get screened starting at 40.
It is approved for the use in the treatment of metastatic colorectal cancer. Bevacizumab targets circulating VEGF ligand. It is approved for use in the treatment of colon cancer, breast cancer, non-small cell lung cancer, and is investigational in the treatment of sarcoma. Its use for the treatment of brain tumors has been recommended. [29]
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In the few individual therapy sessions he received, staff used the time to go over rule violations, such as his misuse of his cell phone. Share Your Story To share a story about your or a loved one’s experience with drug treatment, write to treatmentstories@huffingtonpost.com or leave a voice mail at 860-348-3376 .