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  2. Pregabalin - Wikipedia

    en.wikipedia.org/wiki/Pregabalin

    [105] [106] However, another study found that pregabalin and gabapentin had similar affinities for the human recombinant α 2 δ-1 subunit (K i =32 nM and 40 nM, respectively). [107] In any case, pregabalin is 2 to 4 times more potent than gabapentin as an analgesic [ 102 ] [ 108 ] and, in animals, appears to be 3 to 10 times more potent than ...

  3. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    Gabapentin is recommended for use in focal seizures and neuropathic pain. [7] [10] Gabapentin is prescribed off-label in the US and the UK, [22] [23] for example, for the treatment of non-neuropathic pain, [22] anxiety disorders, sleep problems and bipolar disorder. [24] In recent years, gabapentin has seen increased use, particularly in the ...

  4. Gabapentinoid - Wikipedia

    en.wikipedia.org/wiki/Gabapentinoid

    Similarly, gabapentin enacarbil is transported not by the LAT1 but by the monocarboxylate transporter 1 (MCT1) and the sodium-dependent multivitamin transporter (SMVT), and no saturation of bioavailability has been observed with the drug up to a dose of 2,800 mg. [25] Similarly to gabapentin and pregabalin, baclofen, a close analogue of ...

  5. List of psychotropic medications - Wikipedia

    en.wikipedia.org/wiki/List_of_psychotropic...

    Ambien – nonbenzodiazepine used as a sleep aid Anafranil ( clomipramine ) – a tricyclic antidepressant ; mostly used to treat OCD Antabuse ( disulfiram ) – inhibits the enzyme acetaldehyde dehydrogenase , causing acetaldehyde poisoning when ethanol is consumed; used to cause severe hangover when drinking; increases liver, kidney, and ...

  6. What is gabapentin? Here's why it's so controversial. - AOL

    www.aol.com/gabapentin-heres-why-controversial...

    Gabapentin is a prescription medication that was approved by the U.S. Food and Drug Administration in 1993 as a treatment for epilepsy. It works by binding to a type of calcium channel in nerve ...

  7. Anxiolytic - Wikipedia

    en.wikipedia.org/wiki/Anxiolytic

    Phenibut is a GABA B receptor agonist, [42] as well as an antagonist at α 2 δ subunit-containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin. [44] The medication is not approved by the FDA for use in the United States, but is sold online as a supplement. [45] [46]

  8. Analgesic adjuvant - Wikipedia

    en.wikipedia.org/wiki/Analgesic_adjuvant

    Multimodal analgesia refers to the use of multiple classes of medications in order to treat pain from different molecular mechanisms at once. Prolonged use of higher doses of opioids is associated with increased risk of tolerance and opioid use disorder, so there is a growing trend in the use of multimodal analgesia to treat pain.

  9. 4-Methylpregabalin - Wikipedia

    en.wikipedia.org/wiki/4-Methylpregabalin

    The effectiveness of pregabalin and its older relative gabapentin against pain syndromes of this kind (which tend to respond poorly to other analgesic drugs) has led to their widespread use, and these drugs have subsequently been found to be useful for many other medical applications, including as anticonvulsants, muscle relaxants, anxiolytics ...

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