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Medetomidine is a veterinary anesthetic drug with potent sedative effects and emerging illicit drug adulterant. [ 1 ] It is a racemic mixture of two stereoisomers , levomedetomidine and dexmedetomidine , the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist .
[3] [16] [50] Hypertension followed by hypotension, bradycardia, and respiratory depression lower tissue oxygenation in the skin. [12] Thus, chronic use of xylazine can progress the skin oxygenation deficit, leading to severe skin ulceration. [12] Lower skin oxygenation is associated with impaired healing of wounds and a higher chance of ...
Medetomidine shares similar traits with xylazine, also known as “tranq,” another powerful animal tranquilizer that recently made its way into Wisconsin’s illicit drug market.
The rise of medetomidine comes as overdose deaths have fallen slightly. More than 107,000 people died of a drug overdose last year, down from about 111,000 in 2022, according to a recent report.
Medetomidine, a powerful animal tranquilizer, has emerged as one of the latest substances found mixed with other common street drugs. The drug has recently been cited as the likely culprit behind ...
They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release.
[10] [11] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder. [5] It is administered as an injection or intravenous solution or as a buccal or sublingual film. [1] Similar to clonidine, dexmedetomidine is a sympatholytic drug that acts as an agonist of α 2-adrenergic receptors in certain parts ...
Detomidine is a sedative with analgesic properties. [3] α 2-adrenergic receptor agonists produce dose-dependent sedative and analgesic effects, mediated by activation of α 2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters.