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p3 peptide also known as amyloid β- peptide (Aβ) 17–40/42 is the peptide resulting from the α-and γ-secretase cleavage from the amyloid precursor protein . It is known to be the major constituent of diffuse plaques observed in Alzheimer's disease (AD) brains and pre- amyloid plaques in people affected by Down syndrome .
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Amyloid beta (Aβ) is composed of a family of peptides produced by proteolytic cleavage of the type I transmembrane spanning glycoprotein amyloid-beta precursor protein (APP). Amyloid plaque Aβ protein species ends in residue 40 or 42, [ 4 ] but it is suspected that Aβ42 form is crucial in the pathogenesis of AD.
Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [24] APP is produced by many types of cell in the body, but it is especially abundant in neurons. It is a single-pass transmembrane protein, passing once through cellular ...
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [ 5 ] and has been implicated as a regulator of synapse formation , [ 6 ] neural plasticity , [ 7 ] antimicrobial activity, [ 8 ] and iron export . [ 9 ]
Recamán's sequence: 0, 1, 3, 6, 2, 7, 13, 20, 12, 21, 11, 22, 10, 23, 9, 24, 8, 25, 43, 62, ... "subtract if possible, otherwise add": a(0) = 0; for n > 0, a(n) = a(n − 1) − n if that number is positive and not already in the sequence, otherwise a(n) = a(n − 1) + n, whether or not that number is already in the sequence. A005132: Look-and ...
Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is unclear but thought to be involved in neuronal development. [2] The presenilins are components of proteolytic complex involved in APP processing and degradation. [3] [4]
Abel's uniform convergence test is a criterion for the uniform convergence of a series of functions or an improper integration of functions dependent on parameters. It is related to Abel's test for the convergence of an ordinary series of real numbers, and the proof relies on the same technique of summation by parts. The test is as follows.