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5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
5-HTP is rapidly absorbed with a t max of ≈1.5 h, and rapidly eliminated with a half-life of ≈1.5 – 2 h. Co-administration of a decarboxylase inhibitor (e.g., carbidopa, benserazide ) doubles the half-life of 5-HTP to ≈ 3 – 4 h , [ 37 ] [ 34 ] and enhances exposure several-fold, depending on the dosing regimen.
Nutrition facts: 280 calories. 10 grams of fat. 23 grams of total sugar. 3 grams of protein. Oatmeal and oatmeal bars often appear on lists of the healthiest breakfasts.
This article, in claiming absurdities like that 5-HTP commonly causes vomiting and diarrhea, fails to even come close to representing the truth about 5-HTP, something which is widely available and fails to cause problems for the vast majority of people who use it.
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The amino acid 5-HTP, or 5-hydroxytryptophan, has been anecdotally reported to be a mild anaphrodisiac, as has the serotonergic empathogen MDMA, popularly known as "ecstasy". However, systematic study of these chemicals is lacking, due to the off-patent nature of 5-HTP, and the legal control of MDMA.
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