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The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR associated nucleases) system was originally discovered to be an acquired immune response mechanism used by archaea and bacteria.
ESTs may be used to identify gene transcripts, and were instrumental in gene discovery and in gene-sequence determination. [2] The identification of ESTs has proceeded rapidly, with approximately 74.2 million ESTs now available in public databases (e.g. GenBank 1 January 2013, all species). EST approaches have largely been superseded by whole ...
For each model organism, RefSeq aims to provide separate and linked records for the genomic DNA, the gene transcripts, and the proteins arising from those transcripts. RefSeq is limited to major organisms for which sufficient data are available (121,461 distinct "named" organisms as of July 2022), [ 4 ] while GenBank includes sequences for any ...
Also, transcripts must map to only one other mRNA molecule in order for it to be considered a NAT pair. [1] [7] Currently there are a variety of web and software resources that can be used to look for antisense pairs. The NATsdb or Natural Antisense Transcript database is a rich tool for searching for antisense pairs from multiple organisms.
Each entry is a set of transcripts that appear to stem from the same transcription locus (i.e. gene or expressed pseudogene). Information on protein similarities, gene expression, cDNA clones, and genomic location is included with each entry. Descriptions of the UniGene transcript based and genome based build procedures are available.
UTRs regulate the levels of primary transcript in numerous ways: transcript stability, folding and turnover, as well as translation efficiency. UTRs are often the target of miRNA , which typically downregulate transcript expression by triggering degradation or halting translation.
Fusion transcript is a chimeric RNA encoded by a fusion gene [1] or by two different genes by subsequent trans-splicing. [ 2 ] [ 3 ] Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.
The ORCID (/ ˈ ɔːr k ɪ d / ⓘ; Open Researcher and Contributor ID) is a nonproprietary alphanumeric code to uniquely identify authors and contributors of scholarly communication, [1] as well as ORCID's website and services to look up authors and their bibliographic output (and other user-supplied pieces of information).