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A micronucleus test is a test used in toxicological screening for potential genotoxic compounds. The assay is now recognized as one of the most successful and reliable assays for genotoxic carcinogens, i.e., carcinogens that act by causing genetic damage and is recommended by the OECD guideline for the testing of chemicals. [1]
NaYF 4: Yb 3+ /Tm 3+ nanoparticles with SYBR Green I dye can probe Hg 2+ in vitro with a detection limit of 0.06 nM. Hg 2+ and other heavy metals have been measured in live cells. The tunable and multiplexed emissions allow for the simultaneous detection of different species.
In vitro toxicity testing is the scientific analysis of the toxic effects of chemical substances on cultured bacteria or mammalian cells. [1] In vitro (literally 'in glass') testing methods are employed primarily to identify potentially hazardous chemicals and/or to confirm the lack of certain toxic properties in the early stages of the development of potentially useful new substances such as ...
A method which could help decrease animal testing is the use of in vitro batteries, where several in vitro assays are compiled to cover multiple endpoints. Within developmental neurotoxicity and reproductive toxicity there are hopes for test batteries to become easy screening methods for prioritization for which chemicals to be risk assessed ...
As different radioisotopes have different half-lives, counting can be delayed to allow interfering species to decay eliminating interference. Until the introduction of ICP-AES and PIXE , NAA was the standard analytical method for performing multi-element analyses with minimum detection limits in the sub- ppm range. [ 1 ]
The study of poisons and toxic substances has a long history dating back to ancient times, when humans recognized the dangers posed by various natural compounds. However, the formalization and development of toxicology as a distinct scientific discipline can be attributed to notable figures like Paracelsus (1493–1541) and Orfila (1757–1853).
Toxicity can be tested in vitro and in vivo. In vitro toxicity results can vary depending on the type of the cellular growth media with different protein compositions, the method used to determine cellular toxicity (cell health, cell stress, how many cells are taken into a cell), and the capping ligands in solution. [90]
A number of heavy metals, such as cadmium and lead, are toxic to various forms of life, particularly when dissolved in water as metal ions. [1] Toxic heavy metals are often present in surface water as a result of natural processes, such as the weathering of metal-containing rocks, or due to human activity, such as mining and smelting. [2]