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2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2. It has been used in explosives manufacturing and as a pesticide and herbicide. In humans, DNP causes dose-dependent mitochondrial uncoupling , causing the rapid loss of ATP as heat and leading to uncontrolled hyperthermia —up to 44 °C (111 ...
There are six isomers of dinitrophenol: Chemical structure of 2,4-Dinitrophenol. 2,3-Dinitrophenol; 2,4-Dinitrophenol; 2,5-Dinitrophenol; 2,6-Dinitrophenol; 3,4-Dinitrophenol; 3,5-Dinitrophenol; Dinitrophenols also form the core structure of some herbicides, which are collectively referred to as dinitrophenol herbicides, including: Chemical ...
2,4-Dinitrophenol, a small organic molecule formerly marketed as a pharmaceutical "diet aid"; Deoxyribonucleoprotein, a complex of DNA and protein; Distance to neutral point, a quantity which is important when considering thermal expansion mismatch
2,4-DNP can mean: 2,4-Dinitrophenol , a small organic molecule formerly marketed as a pharmaceutical "diet aid" 2,4-Dinitrophenylhydrazine , Brady's reagent, used in organic chemical analysis
HU6 is a prodrug of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) that is intended to "minimize the rapid absorption and high peak blood concentrations of DNP to provide a wider therapeutic index and improve safety."
The discontinued drug 2,4-dinitrophenol works by increasing energy expenditure by decreasing the efficiency of mitochondria (uncoupling agent). [18] A prodrug of DNP, HU6, has been tested in clinical trials for weight loss and fatty liver disease. [22]
Diazodinitrophenol (DDNP) was the first diazo compound produced; it was subsequently used to make dyes and explosives. It forms yellow crystals in pure form; however, the color of impure forms may vary from dark yellow to green to dark brown. [1]
2,4-Dinitrophenol (DNP) is a very strong thermogenic drug used for fat loss which produces a dose-dependent increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain .