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Protection from bubonic plague. Stephens, et al. (1998), suggest that bubonic plague ( Yersinia pestis ) had exerted positive selective pressure on CCR5 Δ32. [ 43 ] This hypothesis was based on the timing and severity of the Black Death pandemic, which killed 30% of the European population of all ages between 1346 and 1352. [ 63 ]
Bubonic plague is one of three types of plague caused by the bacterium Yersinia pestis. [1] One to seven days after exposure to the bacteria, flu-like symptoms develop. [1] These symptoms include fever, headaches, and vomiting, [1] as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. [2]
Variants linked to protection against the 14th century bubonic plague are also associated with an increased susceptibility to autoimmune diseases. Scientists reveal how Black Death may have ...
The bubonic plague was the most commonly seen form during the Black Death. The bubonic form of the plague has a mortality rate of thirty to seventy-five percent and symptoms include fever of 38–41 °C (101–105 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise.
The gene affects T cell function and provides protection against HIV, smallpox and possibly plague, [51] but for the last, no explanation exists on how it would do that. However, that is now challenged since the CCR5-Δ32 gene has been found to be just as common in Bronze Age tissue samples. [52]
A cohort study, from June 1981 to October 2016, looked into the correlation between the delta 32 deletion and HIV resistance, and found that homozygous carriers of the delta 32 mutation are resistant to M-tropic strains of HIV-1 infection. [10]
A Colorado man caught the rarest and most fatal form of the plague and it can be spread in the air from coughing and sneezing. It's called pneumonic plague.
Pneumonic plague is a severe lung infection caused by the bacterium Yersinia pestis. [3] Symptoms include fever, headache, shortness of breath, chest pain, and coughing. [1] They typically start about three to seven days after exposure. [2] It is one of three forms of plague, the other two being septicemic plague and bubonic plague. [3]