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3398 15902 Ensembl ENSG00000115738 ENSMUSG00000020644 UniProt Q02363 P41136 RefSeq (mRNA) NM_002166 NM_010496 RefSeq (protein) NP_002157 NP_034626 Location (UCSC) Chr 2: 8.68 – 8.68 Mb Chr 12: 25.14 – 25.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. Function The protein encoded by this ...
Four ID proteins exist in humans: ID1, ID2, ID3, and ID4. The ID homologue gene in Drosophila is called extramacrochaetae (EMC) and encodes a transcription factor of the helix-loop-helix family that lacks a DNA binding domain.
It requires Id2 gene, which induce genesis of CD3 − CD4 + CD45 + cells. These cells accumulates on the site of NALT after birth and induce NALT formation. These cells accumulates on the site of NALT after birth and induce NALT formation.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. [5] The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. [5]
Since Myc is an inducer of Id2, downregulating Myc will also result in reduced Id2 signaling, which contributes to cell cycle arrest. [ 31 ] Studies show that Smad3, but not Smad2, is an essential effector for the cytostatic effects of TGF-B. Depleting endogeneous Smad3 via RNA interference was sufficient to interfere with TGF-B cytostasis.
Multiple ETS factors have been found to be associated with cancer, such as through gene fusion. For example, the ERG ETS transcription factor is fused to the EWS gene, resulting in a condition called Ewing's sarcoma. [6] The fusion of TEL to the JAK2 protein results in early pre-B acute lymphoid leukaemia. [7]
ID-2 or ID2 may refer to: ID-2 format, a standard size for identification cards defined by ISO/IEC 7810. A gene called ID2 which negatively regulates cell differentiation. Idaho's 2nd congressional district
This gene encodes a DNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes in B cells of the immune system. [5] [9] AID is currently thought to be the master regulator of secondary antibody diversification ...